In the study, researchers at the College Station, Texas-based university’s Institute for Obesity Research and Program Evaluation, scientists wanted to investigate how mango polyphenols’ anti-inflammatory and cell-toxicity properties affected breast cancer and non-cancer cells, according to a news release.
Earlier research showed that polyphenolic compounds, such as those found in mangoes, possess cancer-fighting properties, Susanne Talcott, the institute’s director, said in the release.
Those compounds appear to possess antioxidant properties that may contribute to decrease oxidative stress, which can lead to the onset of chronic diseases such as cancer and additionally, polyphenolics have been shown to be anti-inflammatory, according to the release.
Researchers extracted polyphenolics from the keitt variety supplied by the National Mango Board in Orlando, Fla.
The scientists treated breast cells infected with and without with mango polyphenolics in different concentrations.
Results of the injections showed polyphenols decreased sample breast cancer cell proliferation by approximately 90% and that the injections decreased the proliferation of sample non-cancer cells by approximately 20%, according to the release.
The study showed mango polyphenols’ cell-killing properties are specific to cancer cells, where inflammation was reduced in both cancer and non-cancer cells, according to the release.
In a second study, researchers found mango polyphenols also suppressed tumor growth and cell proliferation in a breast cancer cell line in hairless mice injected with human breast carcinoma cells, according to the release.