The saying in real estate is location, location, location. And that applies for technology being unveiling by Terrana Biosciences.
Emerging from stealth mode after four years of development, this Flagship Pioneering company is taking the RNA expertise of cousin company Moderna, and creating crop protection solutions in parallel but distinctly different than cousin company Indigo Ag.
“Terrana is coming out of the Flagship Pioneering ecosystem in Boston, and Flagship has a long history of working on RNA,” Ryan Rapp Terrana Biosciences co-founder and CEO. “Probably the best known RNA company is Moderna, but we have a whole host of other ones within the ecosystem, and it’s helped allow us to have all this knowledge about RNA, but apply it to solve problems in agriculture.”
Rapp says RNA is a natural solution to deliver proteins and RNA molecules that can solve many agronomic issues.
“Plants have natural RNAs inside of them that have been evolving with plants for thousands of years. They’ve been largely ignored, because when people are thinking about RNA in plants, they’re usually trying to find things that are making plants sick,” he says. “What Terrana does is we actually look at all the things that everyone else has not had the time to look at and we begin working with those and what we’ve developed from that is a class of three products: prevent, protect and improve.”
Still in pre-commercial phase, Terrana is working on its portfolio of biological RNA-based products that can work like a chassis to carry and deliver protein building information directly to the plant. Protective effects provided by such technologies include anti-insect, nematicidal, antibacterial, and one key solution Terrana is focused on is antivirals.
“We’re looking at some of the vegetable species where today there are severe problems with viruses in the in glass houses and protected culture, particularly like tomatoes,” Rapp says. “We’re working to create viral products that can deliver resistance to several different viruses that when you get them, you kind of have to destroy the whole crop in the greenhouse.”
While the company’s first development focus is specialty crops, Rapp is eyeing opportunities in row crops as well.
“Think about Asian soybean rust in Brazil. You’ve got farmers that are growing three crops of soybean a year down there and spraying up to 16 times. We believe with the way that our technology works we could potentially reduce that to one spray per cropping cycle. So it’s basically three sprays per year,” he says.
New solutions to previously uncontrolled pests, improved application efficicacy and climate resilience are all benefits Rapp says are possible.
He points to cherry orchards in the Pacific Northwest requiring chill hours–hours below 45 degrees Fahrenheit. And farmers have observed warmer winters, which leads to poor flowering, poor fruit set and poor quality fruit.
“Farmers don’t have good options today—they could cut down the cherry trees, move north to Canada, or replace trees with new genetics,” he says. “Terrana’s product lets us do something completely different. We could go in during the summer, spray those trees with our RNA based product, and actually attenuate or turn down the amount of cold hours that they need so that they can go back to being productive farms that are setting high quality fruit. This keeps those flavor profiles, keeps the cherries that consumers have come to love, and gives the economics back to the farmer.”
Terrana is aiming to have commercially available products in the next few years, pending regulatory approval, that can be applied as sprayables or seed treatments. And the company says its RNA-based biologicals can be stored at ambient temperature and will be formulated as stand alone applications or for tank mixes.
